Sodium Cyanide → 2-(2,6-Dimethylpiperidino)amino-3-phenoxypropionitrile

HRID 1089679

반응식

HRID 1089679 반응식
[NH2:1][N:2]1[CH:7]([CH3:8])[CH2:6][CH2:5][CH2:4][CH:3]1[CH3:9].[C-:10]#[N:11].[Na+].[O:13]([CH2:20][CH:21]=O)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>>[CH3:9][CH:3]1[CH2:4][CH2:5][CH2:6][CH:7]([CH3:8])[N:2]1[NH:1][CH:21]([CH2:20][O:13][C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:10]#[N:11]

참가 물질

4

반응물 3

HCID 8929Sodium CyanideHCID 75033PhenoxyacetaldehydeHCID 1234822,6-Dimethyl-1-piperidylamine

생성물 1

HCID 199156542-(2,6-Dimethylpiperidino)amino-3-phenoxypropionitrile수율 76.2%

실험 절차

12.8 g of 1-amino-2,6-dimethylpiperidine, 5.4 g of sodium cyanide and 15.0 g of phenoxyacetaldehyde are reacted analogously to 8a). 20.8 g of 2-(2,6-dimethylpiperidino)amino-3-phenoxypropionitrile are obtained, which are employed in the following step without further purification

출처 및 근거

ORD 기록
ord-6488102a1b7b4334bf2b2615994185af
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05079244

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