Potassium Carbonate → 4-(2-Chloroethoxy)benzamide
반응식
[OH:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1.C1(S(O[CH2:21][CH2:22][Cl:23])(=O)=O)C=CC=CC=1.C(=O)([O-])[O-].[K+].[K+]>CC(=O)CC>[Cl:23][CH2:22][CH2:21][O:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([NH2:8])=[O:7])=[CH:4][CH:3]=1참가 물질
5
실험 절차
A mixture of 4-hydroxybenzamide (194 g, 1.25 M), 2-(benzenesulphonyloxy)ethyl chloride (359 g, 1.8 M), and potassium carbonate (172.8 g, 1.25 M) in butan-2-one (2.16 l) was stirred at reflux for 24 hours. After cooling, distilled water (2.0 l) was added and the resultant precipitate filtered off, washed with water, and dried. Crystallisation from ethanol gave the title compound, yield (232.0 g), m.p. 66°.
후처리
- temperatureat reflux for 24 hours
- temperatureAfter cooling
- distillationdistilled water (2.0 l)
- additionwas added
- filtrationthe resultant precipitate filtered off
- washwashed with water
- customdried
- customCrystallisation from ethanol
출처 및 근거
- ORD 기록
- ord-ff08b8e42c454937acd7702212bbe622
- 출처 데이터셋
- uspto-grants-1992_01
- 특허 번호
- US05079248
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