N-(1-propenyl)piperidine → 1-(4-Fluorophenyl)-4-methyl-5-piperidino-4,5-dihydro-1,2,3-triazole

HRID 1090114노트

반응식

HRID 1090114 반응식
[CH:1]([N:4]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]1)=[CH:2][CH3:3].[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[N+:18]=[N-:19])=[CH:13][CH:12]=1>>[F:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]2[CH:1]([N:4]3[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5]3)[CH:2]([CH3:3])[N:19]=[N:18]2)=[CH:13][CH:12]=1

참가 물질

3

반응물 2

HCID 138954N-(1-propenyl)piperidineHCID 108879741-Azido-4-fluorobenzene

생성물 1

HCID 199146541-(4-Fluorophenyl)-4-methyl-5-piperidino-4,5-dihydro-1,2,3-triazole수율 30.5%

실험 절차

1-(1-propenyl)-piperidine (9.4 g; 75.07 mmol) and 4-fluorophenylazide (10.3 g; 75.07 mmol), prepared as described in example 1, were admixed at 0° C. and the resultant mixture was kept at room temperature for 54 hours in the absence of light. The obtained solid mass was collected with petroleum ether and filtered obtaining the title compound (6 g). The mother liquor was evaporated and the resultant crude compound was purified by chromatography on silica gel (230-400 mesh), eluent petroleum ether:ethyl acetate=9:1, obtaining further title compound (m.p. 75° 76° C.).

후처리

  1. customwere admixed at 0° C.
  2. customThe obtained solid mass was collected with petroleum ether
  3. filtrationfiltered

출처 및 근거

ORD 기록
ord-62ca70e0b3a2422f8caaa317d2c841fc
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05081136

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