2'-Aminoacetophenone → N-(2-Acetylphenyl)thiophene-2-carboxamide

반응식

[C:1]([C:4]1[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=1[NH2:6])(=[O:3])[CH3:2].[C:11]1([C:16](Cl)=[O:17])[S:15][CH:14]=[CH:13][CH:12]=1.C1(C2NC3C(C(=O)C=2)=CC(OC)=C(OC)C=3)CC1>>[C:11]1([C:16]([NH:6][C:5]2[CH:7]=[CH:8][CH:9]=[CH:10][C:4]=2[C:1](=[O:3])[CH3:2])=[O:17])[S:15][CH:14]=[CH:13][CH:12]=1

참가 물질

반응물 3

HCID 110862'-Aminoacetophenone

HCID 789282-Thiophenecarbonyl chloride

HCID 15675273HCID 15675273, 화합물

생성물 1

HCID 218728N-(2-Acetylphenyl)thiophene-2-carboxamide수율 85.4%

실험 절차

2-Acetylaniline (2.0 g) and 2-thenoyl chloride (3.2 g) were condensed in the same manner as in the preparation of compound 95 to obtain N-(2-thenoyl)-2-acetylaniline (3.1 g). The compound (2.0 g) and potassium t-butoxide (9.1 g) were reacted in the same manner as in the preparation of compound 95 to obtain 2-(2-thienyl)-4(1H)-quinolone (compound 100, 310 mg).