3-(1H-imidazol-1-yl)propoxyamine → N-(3-(1H-imidazol-1-yl)propoxy)benz(cd)indol-2-amine

HRID 1090237노트

반응식

HRID 1090237 반응식
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][NH2:10])[CH:5]=[CH:4][N:3]=[CH:2]1.[N:11]1[C:19]2[C:14]3[C:15](=[CH:20][CH:21]=[CH:22][C:13]=3[C:12]=1S)[CH:16]=[CH:17][CH:18]=2>C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][NH:10][C:12]2[C:13]3[CH:22]=[CH:21][CH:20]=[C:15]4[C:14]=3[C:19](=[CH:18][CH:17]=[CH:16]4)[N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

참가 물질

4

반응물 2

HCID 150349943-(1H-imidazol-1-yl)propoxyamineHCID 178527764HCID 178527764, 화합물

생성물 1

HCID 15035031N-(3-(1H-imidazol-1-yl)propoxy)benz(cd)indol-2-amine수율 51.3%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

A mixture consisting of 2.33 grams of 3-(1H-imidazol-1-yl)propoxyamine, 2.84 grams of benz(cd)indol-2-thiol, 4.9 grams of mercuric acetate, and 150 ml of ethanol as stirred and heated under reflux by the conditions of Example 55. The crude product was purified by the chromatographic procedure of Example 46. The resultant orange syrup was recrystallized from ethyl acetate-hexane to give 2.3 grams of the title compound; mp 102° C.-104° C.

후처리

  1. temperatureheated
  2. temperatureunder reflux by the conditions of Example 55
  3. customThe crude product was purified by the chromatographic procedure of Example 46
  4. customThe resultant orange syrup was recrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-92e1a976caa8420f98fd3c40d235ddb5
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05081131

반응 노트

불러오는 중…