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Water → HCID 15035367, 화합물

HRID 1090268
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HRID 1090268 반응식
[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17][CH3:18])=[C:8]2[CH2:19][C:20]([OH:22])=[O:21])=[CH:4][CH:3]=1.[OH:25]OS([O-])=O.[K+].[OH2:31]>C(O)C.[Cl-].[Na+].O.CCOCC>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:6][N:7]2[C:15]3[C:10](=[CH:11][C:12]([F:16])=[CH:13][CH:14]=3)[C:9]([S:17]([CH3:18])(=[O:25])=[O:31])=[C:8]2[CH2:19][C:20]([OH:22])=[O:21])=[CH:23][CH:24]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

7

반응물 3

HCID 962WaterHCID 15035366HCID 15035366, 화합물HCID 23707502Potassium hydroxy sulfite

생성물 1

HCID 15035367HCID 15035367, 화합물

시약·촉매·용매 3

HCID 702Ethanol용매HCID 3283Diethyl Ether용매
HCID 57417360
Sodium chloride; water
용매

실험 절차

To 200 mg of 1-(p-chlorobenzyl)-5-fluoro -3-methylthioindole-2-acetic acid from Example 4 in a mixture of 3 mL water and 3 mL ethanol was added 1.6 g of oxone. After stirring for 6 h the reaction mixture was diluted with brine and ether. The ether layer was washed with 1 N HCl, and brine and dried over MgSO4. Filtration and concentration gave the title compound, mp 202°-202.5°.

후처리

  1. washThe ether layer was washed with 1 N HCl, and brine
  2. dry with materialdried over MgSO4
  3. filtrationFiltration and concentration

출처 및 근거

ORD 기록
ord-0c359762e7df4779900eead826f51e8d
출처 데이터셋
uspto-grants-1992_01
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05081138

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