Peracetic Acid → 4-Acetoxy-2-azetidinone

HRID 1090294

반응식

HRID 1090294 반응식
OC([CH:4]1[NH:7][C:6](=[O:8])[CH2:5]1)=O.[C:9]([O-:12])(=[O:11])[CH3:10].[Na+].C(OO)(=O)C>C(Cl)Cl.C(O)(=O)C.[C].[Ru]>[C:9]([O:12][CH:4]1[NH:7][C:6](=[O:8])[CH2:5]1)(=[O:11])[CH3:10]

참가 물질

7

반응물 3

HCID 6585Peracetic AcidHCID 517045Sodium AcetateHCID 34880644-Oxoazetidine-2-carboxylic acid

생성물 1

HCID 1199814-Acetoxy-2-azetidinone수율 109.9%

시약·촉매·용매 3

HCID 178503044HCID 178503044, 화합물촉매HCID 176Acetic Acid용매2회HCID 6344Dichloromethane용매

반응 조건

온도
0 °C

실험 절차

0.3 g of 4-hydroxycarbonylazetidine-2-one, 0.43 g of anhydrous sodium acetate and 100 mg of 5% ruthenium-carbon were suspended in a mixture of 12 ml of methylene chloride and 4 ml of acetic acid and cooled to -3° C., to which 1.1 ml of acetic acid solution containing 40% peracetic acid was carefully dropped, subjected to stirring at 0° C. for 1 hour. The catalyst was separated by suction filtration, then solvent was distilled off under reduced pressure. 20 ml of n-hexane was added thereto. Undissolved matter was filtered off, the filtrate was concentrated under reduced pressure to obtain 0.37 g of the title compound (yield: 82%).

후처리

  1. additionwas carefully dropped
  2. customThe catalyst was separated by suction filtration
  3. distillationsolvent was distilled off under reduced pressure
  4. addition20 ml of n-hexane was added
  5. filtrationUndissolved matter was filtered off
  6. concentrationthe filtrate was concentrated under reduced pressure

출처 및 근거

ORD 기록
ord-add079eafdf4413e96b6c3205e1426cc
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05081239

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