HCID 14770843, 화합물 → HCID 14770834, 화합물

HRID 1090381노트

반응식

HRID 1090381 반응식
[Br:1][C:2]1[CH:7]=[C:6]([F:8])[C:5]([CH:9]2[CH2:13][CH2:12][CH:11](Cl)[CH2:10]2)=[CH:4][C:3]=1[F:15].[C:16]1(=[O:26])[NH:20][C:19](=[O:21])[C:18]2=[CH:22][CH:23]=[CH:24][CH:25]=[C:17]12.[K]>CN(C)C=O>[Br:1][C:2]1[C:3]([F:15])=[CH:4][C:5]([CH:9]2[CH2:13][CH2:12][CH:11]([N:20]3[C:16](=[O:26])[C:17]4[C:18](=[CH:22][CH:23]=[CH:24][CH:25]=4)[C:19]3=[O:21])[CH2:10]2)=[C:6]([F:8])[CH:7]=1

참가 물질

4

반응물 2

HCID 14770843HCID 14770843, 화합물HCID 24194345Phthalimide potassium salt

생성물 1

HCID 14770834HCID 14770834, 화합물수율 90.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A solution of 29.6 g (0.1 mol) of 1-bromo-4-(3-chlorocyclopentyl)-2,5-difluorobenzene in 150 ml of dry dimethylformamide was treated with 19.4 g (0.105 mol) of potassium phthalimide and the resulting suspension stirred at 100° for 8 hours and room temperature overnight. The solvent was removed in vacuo, and the residue was partitioned between methylene chloride and water. The aqueous layer was reextracted with methylene chloride and the combined organic layers were washed with water, dried (MgSO4), filtered, and evaporated in vacuo to give 36.8 g of the title compound as a viscous oil which crystallized on standing and had mp 44°-47°.

후처리

  1. customThe solvent was removed in vacuo
  2. customthe residue was partitioned between methylene chloride and water
  3. washthe combined organic layers were washed with water
  4. dry with materialdried (MgSO4)
  5. filtrationfiltered
  6. customevaporated in vacuo

출처 및 근거

ORD 기록
ord-a0e178e7814f4da59c8a4b3f2afedf87
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05081254

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