Morpholine → HCID 19913646, 화합물

HRID 1090664노트

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HRID 1090664 반응식
[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:24]1[CH2:26][O:25]1)(=[O:5])[CH2:2][CH2:3][CH3:4].[NH:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1>O1CCOCC1>[C:1]([C:6]1[CH:7]=[N:8][C:9]2[C:14]([C:15]=1[NH:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=1[CH3:23])=[CH:13][CH:12]=[CH:11][C:10]=2[CH:24]([OH:25])[CH2:26][N:27]1[CH2:32][CH2:31][O:30][CH2:29][CH2:28]1)(=[O:5])[CH2:2][CH2:3][CH3:4]

참가 물질

4

반응물 2

HCID 8083MorpholineHCID 99749123-Butyryl-4-(2-methylphenylamino)-8oxiranylquinoline

생성물 1

HCID 19913646HCID 19913646, 화합물수율 47.1%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

3-Butyryl-4-(2-methylphenylamino)-8-oxiranylquinoline (1.0 g, 2.89 mmol) and morpholine (1.0 g, 11.55 mmol) in dioxan (20 ml) were heated under reflux for 9 hours. The dioxan was evaporated and the residue dissolved in ethyl acetate, washed with brine, dried and evaporated to an oil which crystallised from ether. Recrystallisation from dichloromethane/ether gave 3-butyryl-4-(2-methylphenylamino)-8-(1-hydroxy-2-morpholinoethyl)quinoline (0.59 g, 47%), m.p. 135°-137°.

후처리

  1. temperatureunder reflux for 9 hours
  2. customThe dioxan was evaporated
  3. dissolutionthe residue dissolved in ethyl acetate
  4. washwashed with brine
  5. customdried
  6. customevaporated to an oil which
  7. customcrystallised from ether
  8. customRecrystallisation from dichloromethane/ether

출처 및 근거

ORD 기록
ord-36092fa0cd0b4b538eba1e2c7baa52c5
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082841

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