Sodium Bicarbonate → Chromone

HRID 1090780

반응식

HRID 1090780 반응식
C([C:7]1[O:8][C:9]2[CH:17]=[CH:16][C:15](OCC3C=CC=C(OCC4C=CC5C(=CC=CC=5)N=4)C=3)=[CH:14][C:10]=2[C:11](=[O:13])[CH:12]=1)(OCCC)=O.C(=O)(O)[O-].[Na+]>C(O)C.O>[O:13]=[C:11]1[C:10]2[CH:14]=[CH:15][CH:16]=[CH:17][C:9]=2[O:8][CH:7]=[CH:12]1

참가 물질

5

반응물 2

HCID 516892Sodium BicarbonateHCID 199138482-carbopropoxy-6-(3-(quinolin-2-ylmethoxy)benzyloxy)-4-oxo-4H1-benzopyran

생성물 1

HCID 10286Chromone

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

A mixture of 0.71g of 2-carbopropoxy-6-(3-(quinolin-2-yl-methoxy)benzyloxy)-4-oxo-4H-1-benzopyran and 0.45g of sodium bicarbonate in 20 ml of ethanol in 20 ml of water is refluxed for 1.5 hours, then stirred at room temperature overnight. The mixture was neutralized and the resulting solid is filtered off, washed with water and dried in vacuo to give 0.55g of 2-carboxy-6-(3-quinolin-2- ylmethoxy)benzyloxy)-4-oxo-4H-1-benzopyran as a light yellow solid having an m.p. of 253°-54° C.

후처리

  1. temperatureis refluxed for 1.5 hours
  2. filtrationthe resulting solid is filtered off
  3. washwashed with water
  4. customdried in vacuo

출처 및 근거

ORD 기록
ord-1ee73434b9db4f5289f5098d1b7d2d95
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082849

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