Potassium Carbonate → HCID 19913832, 화합물

HRID 1090795노트

반응식

HRID 1090795 반응식
Cl[CH2:2][C:3]1[CH:20]=[CH:19][C:6]([O:7][CH2:8][C:9]2[CH:18]=[CH:17][C:16]3[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=3)[N:10]=2)=[CH:5][CH:4]=1.[C:21]([C:26]1[O:27][C:28]2[C:33]([C:34](=[O:44])[C:35]=1[C:36]1[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][CH:37]=1)=[C:32]([OH:45])[CH:31]=[C:30]([OH:46])[CH:29]=2)([O:23][CH2:24][CH3:25])=[O:22].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[C:21]([C:26]1[O:27][C:28]2[CH:29]=[C:30]([O:46][CH2:2][C:3]3[CH:20]=[CH:19][C:6]([O:7][CH2:8][C:9]4[CH:18]=[CH:17][C:16]5[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=5)[N:10]=4)=[CH:5][CH:4]=3)[CH:31]=[C:32]([OH:45])[C:33]=2[C:34](=[O:44])[C:35]=1[C:36]1[CH:41]=[CH:40][C:39]([O:42][CH3:43])=[CH:38][CH:37]=1)([O:23][CH2:24][CH3:25])=[O:22]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 53801872-Carbethoxy-5,7-dihydroxy-4'-methoxyisoflavoneHCID 147741632-(4-Chloromethylphenoxy)methylquinoline

생성물 1

HCID 19913832HCID 19913832, 화합물

시약·촉매·용매 1

HCID 180Acetone용매

실험 절차

0.62 g of 2-(4-chloromethylphenoxy)methyl quinoline, 0.78 g of 2-carboethoxy-5,7-dihydroxy-4'-methoxy isoflavone and 0.31 g potassium carbonate are refluxed in 30 ml of acetone for 17 hours. The mixture was concentrated and the crude product purified by flash chromatography on silica gel and crystallized from toluene to give 2-carboethoxy-5-hydroxy-3-(4-methoxyphenyl)-7-(4-(quinolin-2- ylmethoxy)benzyloxy)-4-oxo-4H-1-benzopyran.

후처리

  1. concentrationThe mixture was concentrated
  2. customthe crude product purified by flash chromatography on silica gel
  3. customcrystallized from toluene

출처 및 근거

ORD 기록
ord-6a41f468fcf344dfa0b36018d73ab6b9
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05082849

반응 노트

불러오는 중…