Ammonia → HCID 178491593, 화합물

HRID 1091021노트

반응식

HRID 1091021 반응식
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=S)[NH:12][C:13](=[O:22])[C:14]1[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=1)=[O:3].N.OO>CO>[O:3]=[C:2]1[C:4]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:10][C:11]([NH:12][C:13](=[O:22])[C:14]2[CH:19]=[CH:18][C:17]([O:20][CH3:21])=[CH:16][CH:15]=2)=[N:1]1

참가 물질

5

반응물 3

HCID 222AmmoniaHCID 784Hydrogen PeroxideHCID 8928142-[(4-Methoxybenzoyl)carbamothioylamino]benzamide

생성물 1

HCID 178491593HCID 178491593, 화합물수율 10.7%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a stirred mixture of 9.9 g of the above benzamide, 100 ml of methanolic ammonia and 100 ml of methanol was added 22 ml of 30% hydrogen peroxide. The reaction was cooled because of an exotherm and then stirred overnight at room temperature. The solid was collected, partially dissolved in 800 ml of acetonitrile and filtered. The filtrate was chilled, giving 0.95 g of the desired product as white crystals, mp 235°-236° C. (dec.).

후처리

  1. temperatureThe reaction was cooled because of an exotherm
  2. customThe solid was collected
  3. dissolutionpartially dissolved in 800 ml of acetonitrile
  4. filtrationfiltered
  5. temperatureThe filtrate was chilled

출처 및 근거

ORD 기록
ord-794b6dc04f7a436389072b3e9f0f8a8a
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05084457

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