Ammonia → HCID 178425298, 화합물

HRID 1091027

반응식

HRID 1091027 반응식
[NH2:1][C:2]([C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][C:5]=1[NH:10][C:11](=S)[NH:12][C:13](=[O:21])[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=1)=[O:3].N>OO>[O:3]=[C:2]1[C:4]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[NH:10][C:11]([NH:12][C:13](=[O:21])[C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([CH3:20])[CH:15]=2)=[N:1]1

참가 물질

4

반응물 2

HCID 222AmmoniaHCID 667545N-[(2-carbamoylphenyl)carbamothioyl]-3-methylbenzamide

생성물 1

HCID 178425298HCID 178425298, 화합물수율 27.7%

시약·촉매·용매 1

HCID 784Hydrogen Peroxide용매2회

실험 절차

To a stirred mixture of 9.3 g of the above benzamide and 200 ml of methanolic ammonia was added dropwise, 10 ml of 30% hydrogen peroxide over 3 minutes. An exotherm required cooling in an ice bath. A 15 ml portion of 30% hydrogen peroxide was added, the mixture was stirred 48 hours, the solid collected, and mixed with 100 ml of hot water. This solid was collected, mixed with 400 ml of hot acetonitrile and filtered. The filtrate was chilled, giving 2.3 g of the desired product as off-white crystals, mp 211°-213° C.

후처리

  1. additionwas added dropwise
  2. temperatureAn exotherm required cooling in an ice bath
  3. customthe solid collected
  4. additionmixed with 100 ml of hot water
  5. customThis solid was collected
  6. additionmixed with 400 ml of hot acetonitrile
  7. filtrationfiltered
  8. temperatureThe filtrate was chilled

출처 및 근거

ORD 기록
ord-8dc2e2cda81048fc8de8477320eae473
출처 데이터셋
uspto-grants-1992_01
특허 번호
US05084457

연결된 노트

불러오는 중…