Trifluoroacetic acid → HCID 21990122, 화합물
반응식
C([N:14]1[CH2:17][CH:16]([OH:18])[CH2:15]1)(C1C=CC=CC=1)C1C=CC=CC=1.[C:19]([OH:25])([C:21]([F:24])([F:23])[F:22])=[O:20]>CO.[OH-].[Pd+2].[OH-]>[F:22][C:21]([F:24])([F:23])[C:19]([OH:25])=[O:20].[OH:18][CH:16]1[CH2:17][NH:14][CH2:15]1참가 물질
5
실험 절차
1-Benzhydryl-3-hydroxyazetidine (3.0 g, 12.6 mmol) was dissolved in methanol (60 mL), and 10 mL of TFA and 10% palladium hydroxide (1.0 g) were added thereto. The mixture was stirred for 24 hours under a hydrogen stream at normal pressure. The catalyst was removed by filtration, water (100 mL) was added to the filtrate, and the mixture was washed three times with ether. The aqueous layer was concentrated under reduced pressure, and the title compound (2.33 g, 99%) was obtained as an amorphous matter.
후처리
- customThe catalyst was removed by filtration, water (100 mL)
- additionwas added to the filtrate
- washthe mixture was washed three times with ether
- concentrationThe aqueous layer was concentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-7a736cebb3d94cfc9ed81b37c1b4d49a
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08129366B2
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