Acetic Acid → HCID 66591971, 화합물

HRID 1091302노트

반응식

HRID 1091302 반응식
C([N:8]1[CH2:13][CH:12]([CH3:14])[O:11][CH:10]([CH3:15])[CH2:9]1)C1C=CC=CC=1.[C:16]([OH:19])(=[O:18])[CH3:17]>C(O)C.[OH-].[OH-].[Pd+2]>[C:16]([OH:19])(=[O:18])[CH3:17].[CH3:15][CH:10]1[O:11][CH:12]([CH3:14])[CH2:13][NH:8][CH2:9]1

참가 물질

5

반응물 2

HCID 176Acetic AcidHCID 122940934-Benzyl-2,6-dimethylmorpholine

생성물 1

HCID 66591971HCID 66591971, 화합물수율 92%

시약·촉매·용매 2

HCID 9942167Palladium hydroxide촉매HCID 702Ethanol용매

실험 절차

4-Benzyl-2,6-dimethylmorpholine (10.72 mg, 45.76 mmol) was dissolved in acetic acid (10 mL) and ethanol (200 mL), and 10% palladium hydroxide/carbon (5 g) was added thereto. The mixture was stirred for two days at room temperature under a hydrogen stream at normal pressure. The catalyst was separated by filtration, and then the reaction liquor was concentrated under reduced pressure and dried, to obtain the title compound (7.36 g, 92%) as an oily matter. This compound was used in the subsequent reaction without performing further purification.

후처리

  1. customThe catalyst was separated by filtration
  2. concentrationthe reaction liquor was concentrated under reduced pressure
  3. customdried

출처 및 근거

ORD 기록
ord-69a9203784cf4e1faba18f42c935af9c
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129366B2

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