HCID 57599641, 화합물 → HCID 57599653, 화합물

HRID 1091521노트

반응식

HRID 1091521 반응식
[CH3:1][O:2][C:3]1[C:4]([N+:15]([O-])=O)=[C:5]([CH:8]=[CH:9][C:10]=1[O:11][CH2:12][O:13][CH3:14])[C:6]#[N:7]>[Pd].C(O)C>[NH2:15][C:4]1[C:3]([O:2][CH3:1])=[C:10]([O:11][CH2:12][O:13][CH3:14])[CH:9]=[CH:8][C:5]=1[C:6]#[N:7]

참가 물질

4

반응물 1

HCID 57599641HCID 57599641, 화합물

생성물 1

HCID 57599653HCID 57599653, 화합물수율 53.9%

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 702Ethanol용매

실험 절차

To 5% palladium on activated carbon 6.00 g under argon atmosphere was added a solution of 3-methoxy-4-(methoxymethoxy)-2-nitrobenzonitrile 6.00 g (25.2 mmol) in ethanol 50 mL and stirred under hydrogen atmosphere at room temperature for 8 hours. The reaction mixture was filtrated and the filtrate was concentrated in vacuo. Silica gel chromatography (n-hexane/AcOEt=4/1) afforded the title compound 2.83 g as white solid. Yield 53.9%.

후처리

  1. filtrationThe reaction mixture was filtrated
  2. concentrationthe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-90b9ef38eb904fcfa4e3ba5ec6619d0a
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129386B2

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