Water → 4-Morpholino-2-nitrobenzonitrile

HRID 1091531

반응식

HRID 1091531 반응식
[N+:1]([C:4]1[CH:11]=[C:10]([N+:12]([O-])=O)[CH:9]=[CH:8][C:5]=1[C:6]#[N:7])([O-:3])=[O:2].N1[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1.O>CN(C)C=O>[N:12]1([C:10]2[CH:9]=[CH:8][C:5]([C:6]#[N:7])=[C:4]([N+:1]([O-:3])=[O:2])[CH:11]=2)[CH2:20][CH2:19][O:18][CH2:17][CH2:16]1

참가 물질

5

반응물 3

HCID 962WaterHCID 8083MorpholineHCID 5540822,4-Dinitrobenzonitrile

생성물 1

HCID 134992654-Morpholino-2-nitrobenzonitrile수율 82.8%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

A mixture of 2,4-dinitrobenzonitrile 4.20 g (21.75 mmol) and morpholine 5.7 mL (66.0 mmol) in N,N-dimethylformamide 20 mL was stirred at room temperature for 20 hours. The reaction mixture was poured into water. The precipitate was collected and washed with water to give the title compound 4.20 g as orange solid. Yield 74.5%.

후처리

  1. customThe precipitate was collected
  2. washwashed with water

출처 및 근거

ORD 기록
ord-02cebe0ec2ed4d2abe6ec47f4a5a4591
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129386B2

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