Acetic Acid → 4-Hydroxypiperidine-4-carboxamide
반응식
CC(O)=O.C([N:12]1[CH2:17][CH2:16][C:15]([OH:21])([C:18]([NH2:20])=[O:19])[CH2:14][CH2:13]1)C1C=CC=CC=1>CO.[Pd]>[OH:21][C:15]1([C:18]([NH2:20])=[O:19])[CH2:16][CH2:17][NH:12][CH2:13][CH2:14]1참가 물질
5
실험 절차
Pd/C (150 mg) and HOAc (2 mL) are added to a solution of 1-benzyl-4-hydroxy-piperidine-4-carboxylic acid amide (2 g, 8.5 mmol) in MeOH. The mixture is shaken under H2 (40 psi) for 14 h. The catalyst is removed by filtration and the solvent is removed in vacuo to give the title product. 1H NMR (CD3OD) 2.96(m, 4H), 2.05(m, 2H), 1.49 (m, 2H).
후처리
- customThe catalyst is removed by filtration
- customthe solvent is removed in vacuo
출처 및 근거
- ORD 기록
- ord-c6cb701bec8848af80c888abadf3ec7a
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08129395B2
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