Trifluoroacetic acid → 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-yl-pyrimidine Trifluoroacetic Acid Salt

HRID 1091942

반응식

HRID 1091942 반응식
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([CH2:20][O:21][C:22]3[CH:27]=[C:26]([CH:28]([CH3:30])[CH3:29])[CH:25]=[CH:24][C:23]=3[CH3:31])=[C:18]([CH3:32])[N:17]=[C:16]([Cl:33])[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>C(Cl)Cl>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[Cl:33][C:16]1[N:17]=[C:18]([CH3:32])[C:19]([CH2:20][O:21][C:22]2[CH:27]=[C:26]([CH:28]([CH3:29])[CH3:30])[CH:25]=[CH:24][C:23]=2[CH3:31])=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:15]=1

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 575313954-[2-Chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

생성물 1

HCID 866021422-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-yl-pyrimidine Trifluoroacetic Acid Salt

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a solution of 4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (500 mg, 1.05 mmol) in DCM (5 mL) is added trifluoroacetic acid (1 mL) with magnetic stirring. Gas evolution is observed and continues for 20 min. The light yellow colored solution is evaporated at reduced pressure, diluted with DCM (20 mL) and evaporated again. Placed under high vacuum (˜0.2 Torr) for 20 min to obtain the title compound as a colorless oil. LC/MS (Method 2), M+H=432.1, Rt=1.46 min.

후처리

  1. customThe light yellow colored solution is evaporated at reduced pressure
  2. additiondiluted with DCM (20 mL)
  3. customevaporated again
  4. waitPlaced under high vacuum (˜0.2 Torr) for 20 min

출처 및 근거

ORD 기록
ord-683d19f0f3c14ce28352cb288a1fb24a
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129395B2

연결된 노트

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