Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Ethylazepane → 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Ethylazepane | HCID 4335932 | — |
| 반응물 | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| 생성물 | 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine | HCID 59341131 | 97.2% |
반응 단계
0.4 g of 4,6-dichloro-5-fluoropyrimidine and 0.61 g of 2-ethylhexahydro-1H-azepine were mixed and left for 1 hour at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.6 g of 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08129526B2 |
| 출처 데이터셋 | uspto-grants-2012_03 |
| ORD ID | ord-d5869fe331fb4454bc5b9ab8389f9240 |
| 출처 메모 | uspto-grants-2012_03 |