Acetylthiourea → N-[4-Methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-acetamide

HRID 1092960노트

반응식

HRID 1092960 반응식
Br[CH:2]([C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1)[C:3](=O)[CH3:4].[C:15]([NH:18][C:19]([NH2:21])=[S:20])(=[O:17])[CH3:16]>C(O)C>[CH3:4][C:3]1[N:21]=[C:19]([NH:18][C:15](=[O:17])[CH3:16])[S:20][C:2]=1[C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([N+:12]([O-:14])=[O:13])[CH:7]=1

참가 물질

4

반응물 2

HCID 2723593AcetylthioureaHCID 85861734HCID 85861734, 화합물

생성물 1

HCID 85861731N-[4-Methyl-5-(3-nitro-phenyl)-thiazol-2-yl]-acetamide수율 52%

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
70 °C

실험 절차

A mixture of 1-bromo-1-(3-nitro-phenyl)-propan-2-one (Example 49a) (0.5 g, 1.94 mmol) and N-acetylthiourea (0.23 g, 1.94 mmol) in ethanol (10 ml) is stirred at 70° C. for 2 hours. After cooling the reaction to room temperature, the precipitated product is removed by filtration and dried under vacuum to give the titled compound (0.28 g).

후처리

  1. temperatureAfter cooling
  2. customthe reaction to room temperature
  3. customthe precipitated product is removed by filtration
  4. customdried under vacuum

출처 및 근거

ORD 기록
ord-212114c2903e428db869388832887328
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129541B2

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