1-(3-Nitrophenyl)propan-2-one → HCID 85861734, 화합물

HRID 1092982노트

반응식

HRID 1092982 반응식
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11](=[O:13])[CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C1C=C[NH+]=CC=1.[Br:20][Br-]Br>C1COCC1>[Br:20][CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[C:11](=[O:13])[CH3:12]

참가 물질

3

반응물 1

HCID 125079341-(3-Nitrophenyl)propan-2-one

생성물 1

HCID 85861734HCID 85861734, 화합물

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A stirred solution of 3-nitrophenylacetone (2.5 g, 14.0 mmol) in dry THF (50 ml) at room temperature is treated with polymer supported pyridine hydrobromide perbromide (7.0 g, 14.0 mmol) and left to stir overnight. The reaction mixture is then filtered and the solvent removed in vacuo. The residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane to give the titled compound.

후처리

  1. waitleft
  2. filtrationThe reaction mixture is then filtered
  3. customthe solvent removed in vacuo
  4. customThe residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-f67e3f88fc314871a62188dcd41599ea
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08129541B2

반응 노트

불러오는 중…