참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium Chloride | HCID 5234 | — |
| 반응물 | Hydrazine hydrate (1:1) | HCID 24654 | — |
| 반응물 | 5H-Indeno(1,2-b)pyridin-5-one | HCID 77489 | — |
| 용매 | Diethylene Glycol | HCID 8117 | — |
| 생성물 | 4-Azafluorene | HCID 9205 | 99% |
반응 단계
Subsequently, in a stream of argon, 500 mL of diethylene glycol was added to 16.8 g (92.6 mmol) of 4-azafluorene-9-one and 25 mL (370 mmol) of hydrazine monohydrate, and was heated and stirred at 168° C. for 3 hours. After the reaction liquid was cooled to room temperature, an aqueous solution of sodium chloride was added to the reaction liquid, and then, was extracted with ethyl acetate. The organic phase was washed with water, dried over sodium sulfate and concentrated, to thereby obtain 15.3 g of 4-azafluorene (99% yield).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08129899B1 |
|---|
| 출처 데이터셋 | uspto-grants-2012_03 |
|---|
| ORD ID | ord-e5ea128c0996488d818612d85c2ddd28 |
|---|
| 출처 메모 | uspto-grants-2012_03 |
|---|
