{4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrol-2-yl}methanol → 4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

HRID 1093984노트

반응식

HRID 1093984 반응식
[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH2:13][OH:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1>C1COCC1.O=[Mn]=O>[N:1]1([CH2:6][CH2:7][C:8]2[CH:9]=[C:10]([CH:13]=[O:14])[NH:11][CH:12]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 1

HCID 66636497{4-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrol-2-yl}methanol

생성물 1

HCID 866508254-[2-(Pyrrolidin-1-yl)ethyl]-1H-pyrrole-2-carbaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 8028Tetrahydrofuran용매

실험 절차

To a solution of the product obtained in Step I (0.09 g) in THF (3.8 ml) there is added activated MnO2 (0.315 g). After stirring for 20 hours at ambient temperature, the mixture is filtered and the filtrate is evaporated to dryness to yield the title product, which is used directly in the next step.

후처리

  1. filtrationthe mixture is filtered
  2. customthe filtrate is evaporated to dryness

출처 및 근거

ORD 기록
ord-0e7dae2a37bb4753ae5895f28825af2f
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133889B2

반응 노트

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