p-Chlorophenacyl bromide → 1-(4-Chlorophenyl)-2-hydroxyethan-1-one
반응식
Br[CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([Cl:11])=[CH:7][CH:6]=1)=[O:4].C([O-])=[O:13].[K+]>CO>[Cl:11][C:8]1[CH:9]=[CH:10][C:5]([C:3](=[O:4])[CH2:2][OH:13])=[CH:6][CH:7]=1참가 물질
4
실험 절차
A mixture of 2-bromo-1-(4-chloro-phenyl)-ethanone (100 mmoles) and potassium formate (130 mmoles) in MeOH (100 ml) is stirred at reflux for 3 hours. The reaction mixture is poured onto crushed ice. The solid formed is filtered off, washed with cold MeOH and then dried in vacuo to yield the title product, which is used directly in the next Step.
후처리
- temperatureat reflux for 3 hours
- additionThe reaction mixture is poured
- customonto crushed ice
- customThe solid formed
- filtrationis filtered off
- washwashed with cold MeOH
- customdried in vacuo
출처 및 근거
- ORD 기록
- ord-94a9d4d27d194b6e99e35fecac8bb8ed
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08133889B2
반응 노트
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