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Potassium Carbonate → 5,7-dimethyl-2-((1-methyl-4-phenyl-1H-imidazol-2-ylthio)methyl)imidazo[1,2-a]pyrimidine

HRID 1094040
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HRID 1094040 반응식
Cl[CH2:2][C:3]1[N:4]=[C:5]2[N:10]=[C:9]([CH3:11])[CH:8]=[C:7]([CH3:12])[N:6]2[CH:13]=1.[CH3:14][N:15]1[CH:19]=[C:18]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)[NH:17][C:16]1=[S:26].C([O-])([O-])=O.[K+].[K+]>CN(C=O)C>[CH3:12][C:7]1[N:6]2[CH:13]=[C:3]([CH2:2][S:26][C:16]3[N:15]([CH3:14])[CH:19]=[C:18]([C:20]4[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=4)[N:17]=3)[N:4]=[C:5]2[N:10]=[C:9]([CH3:11])[CH:8]=1
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 6933302-(Chloromethyl)-5,7-dimethylimidazo[1,2-a]pyrimidineHCID 201464331-Methyl-4-phenyl-1,3-dihydroimidazole-2-thione

생성물 1

HCID 445487805,7-dimethyl-2-((1-methyl-4-phenyl-1H-imidazol-2-ylthio)methyl)imidazo[1,2-a]pyrimidine수율 468.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide
용매

실험 절차

A mixture of 2-chloromethyl-5,7-dimethyl-imidazo[1,2-a]pyrimidine (1.55 g, 0.8 mmol), 1-methyl-4-phenyl-1,3-dihydro-imidazole-2-thione (1.5 g, 0.8 mmol) and K2CO3 (3.31 g, 2.4 mmol) in dry DMF (20 mL) was stirred under N2 at room temperature overnight. After removal of the solvent under vacuum, the residue was purified by preparative HPLC to afford the title compound (1.31 g, 47%) as a white solid. LC-MS: m/z=350.2 (MH+), tR=2.14 min, method D.

후처리

  1. customAfter removal of the solvent under vacuum
  2. customthe residue was purified by preparative HPLC

출처 및 근거

ORD 기록
ord-d7cdf4fa80d9427d895a7990bb57f76e
출처 데이터셋
uspto-grants-2012_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08133897B2

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