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Ethyl ((5-chlorothiophen-2-yl)sulfonyl)carbamate → 5-chloro-N-({[7-(cyclohexylamino)-6-fluoro-1-isopropyl-4-oxo-1,4-dihydroquinolin-3-yl]amino}carbonyl)thiophene-2-sulfonamide

HRID 1094175
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인쇄 미리보기

반응식

HRID 1094175 반응식
C(O[C:4](=[O:15])[NH:5][S:6]([C:9]1[S:10][C:11]([Cl:14])=[CH:12][CH:13]=1)(=[O:8])=[O:7])C.[NH2:16][C:17]1[C:26](=[O:27])[C:25]2[C:20](=[CH:21][C:22]([NH:29][CH:30]3[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]3)=[C:23]([F:28])[CH:24]=2)[N:19]([CH:36]([CH3:38])[CH3:37])[CH:18]=1>C1(C)C=CC=CC=1>[Cl:14][C:11]1[S:10][C:9]([S:6]([NH:5][C:4]([NH:16][C:17]2[C:26](=[O:27])[C:25]3[C:20](=[CH:21][C:22]([NH:29][CH:30]4[CH2:35][CH2:34][CH2:33][CH2:32][CH2:31]4)=[C:23]([F:28])[CH:24]=3)[N:19]([CH:36]([CH3:38])[CH3:37])[CH:18]=2)=[O:15])(=[O:7])=[O:8])=[CH:13][CH:12]=1
참가 물질반응 조건실험 절차후처리출처 및 근거반응 노트

참가 물질

4

반응물 2

HCID 24778122Ethyl ((5-chlorothiophen-2-yl)sulfonyl)carbamateHCID 666370233-amino-7-(cyclohexylamino)-6-fluoro-1-isopropylquinolin-4(1H)-one

생성물 1

HCID 666369105-chloro-N-({[7-(cyclohexylamino)-6-fluoro-1-isopropyl-4-oxo-1,4-dihydroquinolin-3-yl]amino}carbonyl)thiophene-2-sulfonamide수율 65.7%

시약·촉매·용매 1

HCID 1140Toluene용매

반응 조건

온도
110 °C

실험 절차

287 mg of ethyl[(5-chloro-2-thienyl)sulfonyl]carbamate was dissolved in 5.0 ml of toluene, and 250 mg of 3-amino-7-(cyclohexylamino)-6-fluoro-1-isopropylquinolin-4(1H)-one was added, followed by overnight stirring at 110° C. The reaction mixture was cooled to room temperature and concentrated under a reduced pressure. Then, ethyl acetate was added and the insoluble materials were collected by filtration, thereby obtaining 280 mg of 5-chloro-N-({[7-(cyclohexylamino)-6-fluoro-1-isopropyl-4-oxo-1,4-dihydroquinolin-3-yl]amino}carbonyl)thiophene-2-sulfonamide.

후처리

  1. temperatureThe reaction mixture was cooled to room temperature
  2. concentrationconcentrated under a reduced pressure
  3. additionThen, ethyl acetate was added
  4. filtrationthe insoluble materials were collected by filtration

출처 및 근거

ORD 기록
ord-4cc454791ce245559e1237d09c4a8442
출처 데이터셋
uspto-grants-2012_03
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08133882B2

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