Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
1-ethyl-3-methyl-1H-pyrazol-4-amine → (1-Ethyl-3-methyl-1H-pyrazol-4-yl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 1-ethyl-3-methyl-1H-pyrazol-4-amine | HCID 6485354 | — |
| 반응물 | 3-Pyridineacetonitrile, 6-(trifluoromethyl)- | HCID 50851127 | — |
| 촉매 | Palladium | HCID 23938 | — |
| 용매 | Methanol | HCID 887 | — |
| 생성물 | (1-Ethyl-3-methyl-1H-pyrazol-4-yl)-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-amine | HCID 58007521 | 13% |
반응 단계
A solution of 1-ethyl-3-methyl-1H-pyrazol-4-ylamine (1.345 g, 10.75 mmol, commercially available) and (6-trifluoromethyl-pyridin-3-yl)-acetonitrile (distilled 166-175° C./2 mb, 1.0 g, 5.4 mmol) in MeOH (10 mL) was treated with HCO2NH4 (1.694 g, 26.86 mmol) and 10% Pd/C (200 mg) and stirred at 80° for 1.5 h. Filtration, concentration and purification by HPLC afforded the title compound (0.213 g, 13%) as a light brown oil. MS m/e: 299.3 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08133909B2 |
| 출처 데이터셋 | uspto-grants-2012_03 |
| ORD ID | ord-5c4b8b4faffd4ba9b1da5ef83f166845 |
| 출처 메모 | uspto-grants-2012_03 |