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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1094402생성일: 2026년 10월 26일

5-Amino-2-methylpyridine → (S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(6-methyl-pyridin-3-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamide

https://huagongshe.com/reaction/1094402

반응식

참여 물질

역할이름HCID투입량
반응물5-Amino-2-methylpyridineHCID 243313—
반응물2-(4-Fluorophenyl)-2-oxoacetic AcidHCID 579440—
반응물3-Pyridineacetonitrile, 6-(trifluoromethyl)-HCID 50851127—
생성물(S)-2-(4-Fluoro-phenyl)-2-hydroxy-N-(6-methyl-pyridin-3-yl)-N-[2-(6-trifluoromethyl-pyridin-3-yl)-ethyl]-acetamideHCID 58007552—

반응 단계

In analogy to example 47, steps 2, 3 & 4, 6-Methyl-pyridin-3-ylamine, (6-Trifluoromethyl-pyridin-3-yl)-acetonitrile & (4-Fluoro-phenyl)-oxo-acetic acid were successively coupled and reduced to give after separation by chromatography on a chiral column (+ve rotation) the target compound. MS(m/e): 434.1 [M+H]+.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US08133909B2
출처 데이터셋uspto-grants-2012_03
ORD IDord-9b4a7c427a3346b986d99cfd938fc439
출처 메모uspto-grants-2012_03