Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl iodide → 4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl iodide | HCID 6328 | — |
| 반응물 | beta,beta-Dimethyl-1H-indole-3-ethanamine | HCID 27303 | — |
| 반응물 | tert-Butyl 3-(cyanomethyl)-1H-indole-1-carboxylate | HCID 15378323 | — |
| 생성물 | 4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester | HCID 66640193 | — |
반응 단계
4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester was prepared in a manner similar to that described in Example 66A by replacing tryptamine-HCl with 2-(1H-indol-3-yl)-2-methylpropylamine, which was synthesized using 2 equivalents of iodomethane during alkylation of (1-tert-butoxycarbonylindol-3-yl)acetonitrile as described in Example 32B; MS (ESI): 273 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08133992B2 |
| 출처 데이터셋 | uspto-grants-2012_03 |
| ORD ID | ord-6c58ebbd58174390a0fb835cfc526589 |
| 출처 메모 | uspto-grants-2012_03 |