Sulfoxonium, trimethyl-, iodide (1:1) → Methyl 2-(1-methylcyclopropyl)quinoline-6-carboxylate

HRID 1094655노트

반응식

HRID 1094655 반응식
[I-].C[S+](C)(C)=O.[CH3:7]C(C)([O-])C.[K+].[C:13]([C:16]1[CH:25]=[CH:24][C:23]2[C:18](=[CH:19][CH:20]=[C:21]([C:26]([O:28][CH3:29])=[O:27])[CH:22]=2)[N:17]=1)([CH3:15])=[CH2:14]>CS(C)=O.C1COCC1.C1COCC1>[CH3:29][O:28][C:26]([C:21]1[CH:22]=[C:23]2[C:18](=[CH:19][CH:20]=1)[N:17]=[C:16]([C:13]1([CH3:7])[CH2:15][CH2:14]1)[CH:25]=[CH:24]2)=[O:27]

참가 물질

6

반응물 3

HCID 74498Sulfoxonium, trimethyl-, iodide (1:1)HCID 23665647Potassium tert-butoxideHCID 66637151Methyl 2-isopropenylquinoline-6-carboxylate

생성물 1

HCID 66636963Methyl 2-(1-methylcyclopropyl)quinoline-6-carboxylate수율 68.1%

시약·촉매·용매 2

HCID 8028Tetrahydrofuran용매HCID 21830753dimethylsulfoxide THF용매

실험 절차

To a stirred suspension of trimethylsulfoxonium iodide (435 mg, 2.06 mmol) in dimethylsulfoxide-THF (3 ml-2 ml) was added potassium t-butoxide (231 mg, 2.06 mmol) in one portion at ambient temperature. After 30 min. at same temperature, to this (colorless solution) was added a solution of methyl 2-isopropenylquinoline-6-carboxylate (312 mg, 1.37 mmol) in THF (3 ml) at room temperature. The mixture was stirred at room temperature for 40 min then 1 hour at 60° C. The mixture was quenched with water and diluted with ethyl acetate-toluene (8:1) (90 ml). The organic solution was separated and washed with water (×2), brine, dried over sodium sulfate and concentrated in vacuo to crude product. The crude product was purified by column chromatography on silica gel (250 g) with hexane-ethyl acetate (10:1) to furnish the title compound (225 mg, 68%) as a white solid. 1H NMR (270 MHz, CDCl3) δ ppm 0.91-0.98 (2H, m), 1.38-1.45 (2H, m), 1.64 (3H, s), 3.98 (3H, s), 7.42-7.48 (1H, m), 7.97-8.27 (3H, m), 8.50-8.55 (1H, m). MS (ESI): m/z 242.15 (M+H)+.

후처리

  1. custom1 hour
  2. customat 60° C
  3. customThe mixture was quenched with water
  4. additiondiluted with ethyl acetate-toluene (8:1) (90 ml)
  5. customThe organic solution was separated
  6. washwashed with water (×2), brine
  7. dry with materialdried over sodium sulfate
  8. concentrationconcentrated in vacuo to crude product
  9. customThe crude product was purified by column chromatography on silica gel (250 g) with hexane-ethyl acetate (10:1)

출처 및 근거

ORD 기록
ord-403c74f9213d4d1aa9a0fdf33ce7a822
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08134004B2

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