Ammonium → 4-chloro-1H-pyrrole-2-carboxamide

HRID 1094874

반응식

HRID 1094874 반응식
ClC(Cl)(Cl)[C:3]([C:5]1[NH:6][CH:7]=[C:8]([Cl:10])[CH:9]=1)=[O:4].[NH4+:13]>C1COCC1>[Cl:10][C:8]1[CH:9]=[C:5]([C:3]([NH2:13])=[O:4])[NH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 223AmmoniumHCID 71306882,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one

생성물 1

HCID 552075774-chloro-1H-pyrrole-2-carboxamide수율 92%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 2,2,2-trichloro-1-(4-chloro-1H-Pyrrol-2-yl)ethanone (14.0 g, 56.7 mmol) in THF (100 mL) was bubbled with ammonium gas for 2 h at room temperature. TLC analysis indicated that there was complete conversion of starting material. The reaction mixture was concentrated in vacuo to yield 7.5 g of the above compound (51.88 mmol, yield 92%). 1H-NMR (Acetone-d6) δ 10.92 (br s, 1H), 7.21 (br s, 1H), 7.02 (s, 1H), 6.84 (s, 1H), 6.57 (br s, 1H).

후처리

  1. concentrationThe reaction mixture was concentrated in vacuo

출처 및 근거

ORD 기록
ord-ea773c68d66d43b68f03ceb3da912e31
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08133995B2

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