Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Acetyl chloride → 1-[5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Acetyl chloride | HCID 6367 | — |
| 반응물 | Trimethylsilane | HCID 70435 | — |
| 반응물 | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| 반응물 | 5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)benzaldehyde | HCID 57743182 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | 1-[5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene | HCID 66641230 | — |
반응 단계
In a manner similar to the method described in Example 112b, 5-fluoro-2-(tetrahydro-thiopyran-4-yloxy)-benzaldehyde was treated with LHMDS, acetyl chloride, triethylamine and trimethyl silane to give the desired compound, which was directly used for the next step.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08134001B2 |
| 출처 데이터셋 | uspto-grants-2012_03 |
| ORD ID | ord-3ae3bfe9706b46dcb457e63e0b627a3d |
| 출처 메모 | uspto-grants-2012_03 |