Hydrochloride methanol → 1-(3-Amino-3-methyl-butyl)-1,3-dihydro-benzimidazol-2-one

반응식

[CH3:1][C:2]([NH:16]C=O)([CH3:15])[CH2:3][CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6]1=[O:14].Cl.CO>>[NH2:16][C:2]([CH3:15])([CH3:1])[CH2:3][CH2:4][N:5]1[C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][C:8]=2[NH:7][C:6]1=[O:14]

참가 물질

반응물 2

HCID 21893726Hydrochloride methanol

HCID 60209130HCID 60209130, 화합물

생성물 1

HCID 131744871-(3-Amino-3-methyl-butyl)-1,3-dihydro-benzimidazol-2-one

실험 절차

A mixture of N-[1,1-dimethyl-3-(2-oxo-2,3-dihydro-1H-benzimidazol-1-yl)propyl]formamide (1.1 g) and hydrogen chloride-methanol (80-90% methanol, 18 mL) was stirred at rt for 50 h. The mixture was concentrated in vacuo and the residue was basified by aq. potassium carbonate and the mixture was extracted with dichloromethane. The combined organic layers were dried over sodium sulfate and concentrated to give 0.81 g (3.7 mmol, 73% for 3 steps) of the title compound.

후처리

concentrationThe mixture was concentrated in vacuo
extractionthe mixture was extracted with dichloromethane
dry with materialThe combined organic layers were dried over sodium sulfate
concentrationconcentrated

출처 및 근거

ORD 기록: ord-c1ca561ee14c4682a0fb1bc14272255a
출처 데이터셋: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08138177B2

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