Sulfuric Acid → 4,6-Dichloroisatin

HRID 1095519

반응식

HRID 1095519 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([NH:9][C:10](=[O:14])[CH:11]=NO)[CH:5]=[C:6]([Cl:8])[CH:7]=1.S(=O)(=O)(O)[OH:16]>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]2[C:3]=1[C:11](=[O:16])[C:10](=[O:14])[NH:9]2

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 71353147N-(3,5-Dichlorophenyl)-2-(hydroxyimino)acetamide

생성물 1

HCID 2519084,6-Dichloroisatin수율 81%

반응 조건

온도
90 °C

실험 절차

The N-(3,5-dichlorophenyl)-2-hydroxyiminoacetamide just prepared (12.1 g, 0.052 mol) was added to 96 per cent strength sulfuric acid (56 ml) at 50-75° C. in the course of 15 min. The reaction mixture was then heated at 90° C. for 15 min, while stirring. After cooling, the mixture was poured slowly on to ice (500 g). The solid formed was filtered off with suction after 30 min. The desired isatin was isolated in a yield of 81% (9.12 g) as an orange-coloured solid. It was not possible to determine a melting point.

후처리

  1. temperatureAfter cooling
  2. customThe solid formed
  3. filtrationwas filtered off with suction after 30 min

출처 및 근거

ORD 기록
ord-1945cd6d6fdf4c8a945f9b5cb2a0e64c
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138187B2

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