3-(2-Bromoethyl)indole → Indole, 3-(2-(isoindolin-2-yl)ethyl)-

HRID 1095530노트

반응식

HRID 1095530 반응식
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[CH:13]1[NH:14][CH:15]=[C:16]2[C:21]=1[CH:20]=[CH:19][CH:18]=[CH:17]2>O1CCOCC1>[CH2:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][N:14]1[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

참가 물질

4

반응물 2

HCID 769243-(2-Bromoethyl)indoleHCID 3013853Isoindole

생성물 1

HCID 39465Indole, 3-(2-(isoindolin-2-yl)ethyl)-

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

A solution of 3-(2-bromo-ethyl)-1H-indole (4.48 g, 20 mmol) and isoindole (4.76 g, 40 mmol) in abs. dioxane (50 ml) was stirred at 80° C. for 6 h. The solvent was then removed i. vac., CHCl3 (100 ml) was added to the residue and the mixture was washed twice with water. The organic phase was dried over Na2SO4 and concentrated i. vac. and the residue which remained was purified by flash chromatography with CHCl3/MeOH (20:1).

후처리

  1. customThe solvent was then removed i
  2. addition, CHCl3 (100 ml) was added to the residue
  3. washthe mixture was washed twice with water
  4. dry with materialThe organic phase was dried over Na2SO4
  5. concentrationconcentrated i
  6. customand the residue which remained was purified by flash chromatography with CHCl3/MeOH (20:1)

출처 및 근거

ORD 기록
ord-bc4bcb7578264a7e9adcb73371d5f13f
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138187B2

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