참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Pyrrolidine | HCID 31268 | — |
| 반응물 | 3-(2-Bromoethyl)indole | HCID 76924 | — |
| 용매 | 1,4-Dioxane | HCID 31275 | — |
| 생성물 | Pyr-T | HCID 26393 | — |
반응 단계
Pyrrolidine (3.17 g, 3.7 ml, 44.6 mmol) was dissolved in abs. dioxane (100 ml), 3-(2-bromo-ethyl)-1H-indole (5 g, 22.3 mmol) was added at RT and the mixture was stirred at 70° C. for 8 h. The solution was concentrated, the residue was taken up in CHCl3 (150 ml) and the mixture was washed with water (2×50 ml). The organic phase was dried over Na2SO4, filtered and concentrated i. vac.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US08138187B2 |
|---|
| 출처 데이터셋 | uspto-grants-2012_03 |
|---|
| ORD ID | ord-58b2bc03adfe4abaa198417af802bb37 |
|---|
| 출처 메모 | uspto-grants-2012_03 |
|---|
