Tryptamine → Tryptamide

HRID 1095550

반응식

HRID 1095550 반응식
[NH2:1][CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.Cl.[C:14](Cl)(=[O:21])[C:15]1[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=1>C1COCC1>[NH:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][NH:1][C:14](=[O:21])[C:15]2[CH:20]=[CH:19][CH:18]=[N:17][CH:16]=2)=[CH:5]1

참가 물질

4

반응물 2

HCID 1150TryptamineHCID 884383-Pyridinecarbonyl chloride, hydrochloride (1:1)

생성물 1

HCID 65768Tryptamide

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

Tryptamine (640 mg, 4.0 mmol) was initially introduced into abs. THF (30 ml). TEA (596 μl, 4.3 mmol) and nicotinic acid chloride hydrochloride (770 mg, 4.3 mmol) was then added and the mixture was stirred at RT for 5 h. The mixture was concentrated to dryness i. vac. The residue was taken up in EA (20 ml) and the mixture was washed with saturated NaHCO3 solution (2×20 ml) and with NaCl solution (2×20 ml). The organic phase was dried over Na2SO4 and concentrated i. vac. Yield: 482 mg (45%)

후처리

  1. concentrationThe mixture was concentrated to dryness i
  2. washthe mixture was washed with saturated NaHCO3 solution (2×20 ml) and with NaCl solution (2×20 ml)
  3. dry with materialThe organic phase was dried over Na2SO4
  4. concentrationconcentrated i

출처 및 근거

ORD 기록
ord-84a9b1ea3e754e9fb269f3e7044c6d71
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138187B2

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