Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Potassium Carbonate → 4-(4-Acetyl-3-chlorophenoxy)benzonitrile
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 4-Cyanophenol | HCID 13019 | — |
| 반응물 | 2'-Chloro-4'-fluoroacetophenone | HCID 2736507 | — |
| 반응물 | Ethylacetate heptane | HCID 21899848 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | 4-(4-Acetyl-3-chlorophenoxy)benzonitrile | HCID 64335501 | — |
반응 단계
To a solution 4-cyanophenol (CAS Reg. No. 767-00-0, 1.2 g), 2-chloro-4-fluoroacetophenone (CAS Reg. No. 700-35-6, 1.7 g) in DMA (10 ml) was added K2CO3 (1.66 g). The mixture is refluxed for 5 h. TLC (heptane/EtOAc 2:1) showed complete conversion. Water was added and the mixture was extracted with DCM. The combined organic layers were dried over Na2SO4 and then concentrated to an oil. The residue was purified by flash chromatography (SiO2, EtOAc/heptane 1:2) to give the title compound (1.8 g) as yellow oil. MS (m/e)=272.2 [M+H+].
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08138189B2 |
| 출처 데이터셋 | uspto-grants-2012_03 |
| ORD ID | ord-dc8398acd11a40ffbe7b23aa940ad840 |
| 출처 메모 | uspto-grants-2012_03 |