(4-Chloro-3-(ethoxycarbonyl)phenyl)boronic acid → HCID 66782596, 화합물

HRID 1095986

반응식

HRID 1095986 반응식
Br[C:2]1[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([C:15]2[CH:16]=[CH:17][C:18](=[O:22])[N:19]([CH3:21])[CH:20]=2)([OH:14])[C:10]([F:13])([F:12])[F:11])=[C:4]([Cl:24])[CH:3]=1.[Cl:25][C:26]1[CH:31]=[CH:30][C:29](B(O)O)=[CH:28][C:27]=1[C:35]([O:37]CC)=[O:36]>>[Cl:25][C:26]1[CH:31]=[CH:30][C:29]([C:2]2[CH:7]=[CH:6][C:5]([CH:8]([CH3:23])[C:9]([OH:14])([C:15]3[CH:16]=[CH:17][C:18](=[O:22])[N:19]([CH3:21])[CH:20]=3)[C:10]([F:13])([F:12])[F:11])=[C:4]([Cl:24])[CH:3]=2)=[CH:28][C:27]=1[C:35]([OH:37])=[O:36]

참가 물질

3

반응물 2

HCID 44119820(4-Chloro-3-(ethoxycarbonyl)phenyl)boronic acidHCID 574213205-[2-(4-bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one

생성물 1

HCID 66782596HCID 66782596, 화합물

실험 절차

In analogy to Example 150, step 2, 5-[2-(4-bromo-2-chloro-phenyl)-1-hydroxy-1-trifluoromethyl-propyl]-1-methyl-1H-pyridin-2-one (Example 165, step 3) was reacted with 4-chloro-3-ethoxycarbonylphenylboronic acid. The product of this reaction was hydrolyzed in analogy to Example 141 to give the title compound as a colorless solid. MS (m/e, ISP neg. ion)=498.1 [M−H+].

출처 및 근거

ORD 기록
ord-67cd69007a0349f1871897201bff6013
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138189B2

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