2,2,2-Trifluoroethyl trifluoromethanesulfonate → 4-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

반응식

[I:1][C:2]1[CH:7]=[CH:6][NH:5][C:4](=[O:8])[CH:3]=1.FC(F)(F)S(O[CH2:15][C:16]([F:19])([F:18])[F:17])(=O)=O>>[I:1][C:2]1[CH:7]=[CH:6][N:5]([CH2:15][C:16]([F:19])([F:18])[F:17])[C:4](=[O:8])[CH:3]=1

참가 물질

반응물 2

HCID 803662,2,2-Trifluoroethyl trifluoromethanesulfonate

HCID 205825354-Iodo-1,2-dihydropyridin-2-one

생성물 1

HCID 667369834-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one

실험 절차

4-iodo-1-(2,2,2-trifluoroethyl)pyridin-2(1H)-one was prepared from 4-iodopyridin-2(1H)-one and 2,2,2-trifluoroethyl trifluoromethanesulfonate following a procedure analogous to that described in Example 59 Step 1.

출처 및 근거

ORD 기록: ord-7762185490044062b8be88b6992e009b
출처 데이터셋: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08138178B2

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