Triethylamine → 2-(2-Oxazolinyl)pyridine

HRID 1096552노트

반응식

HRID 1096552 반응식
[CH2:1]([N:3](CC)CC)[CH3:2].Cl.[NH2:9][C@@H:10]([CH2:13][CH:14]1[CH2:19][CH2:18]CCC1)[CH2:11][OH:12]>C(Cl)Cl>[N:9]1[CH:18]=[CH:19][CH:14]=[CH:13][C:10]=1[C:11]1[O:12][CH2:2][CH2:1][N:3]=1

참가 물질

4

반응물 2

HCID 8471TriethylamineHCID 16212813(2S)-2-amino-3-cyclohexylpropan-1-ol hydrochloride

생성물 1

HCID 154269572-(2-Oxazolinyl)pyridine

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
50 °C

실험 절차

Methyl-6-phenylpyridyl-2-imidate (0.160 g, 0.754 mmol) was dissolved in CH2Cl2 (3 mL). Triethylamine (0.12 mL, 0.83 mmol) was added followed by 2-(S)-amino-3-cyclohexylpropanol hydrochloride (0.161 g, 0.829 mmol). The reaction vessel was sealed and heated on a heating block (50° C.) for 16 hours and the resultant solution was then filtered to remove the insoluble salts. The filtrate was loaded onto the top of a Biotage cartridge (silica gel, 40S) and the product was eluted using a stepped gradient of 0 to 30% ethyl acetate in hexanes as the eluent. The product was obtained after evaporation of the eluent as a slightly yellow solid (0.181 g, 75%).

후처리

  1. customThe reaction vessel was sealed
  2. filtrationthe resultant solution was then filtered
  3. customto remove the insoluble salts
  4. washthe product was eluted
  5. customThe product was obtained
  6. customafter evaporation of the eluent as a slightly yellow solid (0.181 g, 75%)

출처 및 근거

ORD 기록
ord-b10be19e57c84d6bb0cfaa769c38af08
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138348B2

반응 노트

불러오는 중…