1,1'-Carbonyldiimidazole → 2H-Benzimidazol-2-one, 1,3-dihydro-1-(2-methoxyethyl)-
반응식
[CH3:1][O:2][CH2:3][CH2:4][NH:5][C:6]1[C:7]([NH2:12])=[CH:8][CH:9]=[CH:10][CH:11]=1.C1N=CN([C:18](N2C=NC=C2)=[O:19])C=1>C1COCC1>[CH3:1][O:2][CH2:3][CH2:4][N:5]1[C:6]2[CH:11]=[CH:10][CH:9]=[CH:8][C:7]=2[NH:12][C:18]1=[O:19]참가 물질
4
실험 절차
The residue 109B (422 mg, 2.54 mmol) was dissolved in THF (7.5 mL). CDI (494 mg, 3.05 mmol) in THF (7.6 mL) was added slowly via addition funnel. After addition the mixture was stirred overnight at room temperature, solvent was removed under vacuum. The residue was purified by column chromatography (5% MeOH/DCM) to give the product 1-(2-methoxyethyl)-1H-benzo[d]imidazol-2(3H)-one (109C) as an orange solid (449 mg, 92%). ESI-MS:m/z 193.3 (M+H)+.
후처리
- additionAfter addition the mixture
- customsolvent was removed under vacuum
- customThe residue was purified by column chromatography (5% MeOH/DCM)
출처 및 근거
- ORD 기록
- ord-4ede0777ad9f4c1ba9201627499b8712
- 출처 데이터셋
- uspto-grants-2012_03
- 특허 번호
- US08138168B1
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