Sulfuric Acid → HCID 178438224, 화합물

반응식

[CH2:1]([C:3]1([CH:8]([F:13])[C:9]([NH:11][OH:12])=[O:10])OCCO1)[CH3:2].OS(O)(=O)=O>>[CH2:1]([C:3]1[O:12][N:11]=[C:9]([OH:10])[C:8]=1[F:13])[CH3:2]

참가 물질

반응물 2

HCID 1118Sulfuric Acid

HCID 866370552-(2-Ethyl-[1,3]dioxolan-2-yl)-2-fluoro-N-hydroxyacetamide

생성물 1

HCID 178438224HCID 178438224, 화합물수율 82.1%

실험 절차

A sol. of 2-(2-ethyl-[1,3]dioxolan-2-yl)-2-fluoro-N-hydroxyacetamide (502 mg, 2.60 mmol) in cone. H2SO4 (1.2 mL) was stirred for 2 h at rt, then for 2 h at 50° C. The mixture was poured onto ice, and this mixture was extracted with EtOAc. The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the title compound (280 mg, 82%). LC-MS: tR=0.66, ES+: not visible.

후처리

additionThe mixture was poured onto ice
extractionthis mixture was extracted with EtOAc
dry with materialextracts were dried over MgSO4
filtrationfiltered
customthe solvents were removed under reduced pressure
customDrying the residue under high vacuum

출처 및 근거

ORD 기록: ord-34d778ebad034d348b7d33d7373bd868
출처 데이터셋: uspto-grants-2012_03
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08138340B2

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