2-Methyl-3-(trifluoromethyl)benzyl alcohol → 2-Methyl-3-(trifluoromethyl)benzaldehyde

HRID 1096831노트

반응식

HRID 1096831 반응식
[CH3:1][C:2]1[C:9]([C:10]([F:13])([F:12])[F:11])=[CH:8][CH:7]=[CH:6][C:3]=1[CH2:4][OH:5]>C(Cl)Cl.O=[Mn]=O>[CH3:1][C:2]1[C:9]([C:10]([F:11])([F:12])[F:13])=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[O:5]

참가 물질

4

반응물 1

HCID 27756102-Methyl-3-(trifluoromethyl)benzyl alcohol

생성물 1

HCID 37191482-Methyl-3-(trifluoromethyl)benzaldehyde

시약·촉매·용매 2

HCID 14801Manganese dioxide촉매HCID 6344Dichloromethane용매

실험 절차

To a sol. of 2-methyl-3-trifluoromethylbenzyl alcohol (0.500 g, 2.63 mmol) in CH2Cl2 (25 mL) was added activated MnO2 (2.29 g, 26.3 mmol). After stirring for 72 h, the mixture was filtered over Celite, and the solvents were removed under reduced pressure. The aldehyde is used in the next step without further purification. 1H NMR (CDCl3) δ 10.40 (s, 1H), 8.00 (d, 1H), 7.85 (d, 1H), 7.45 (t, 1H), 2.8 (s, 3H).

후처리

  1. filtrationthe mixture was filtered over Celite
  2. customthe solvents were removed under reduced pressure
  3. customThe aldehyde is used in the next step without further purification

출처 및 근거

ORD 기록
ord-8d06c68ad251450f9c1b069ecc633508
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138340B2

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