Phenol, 2,6-dichloro-4-fluoro- → 6-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-{2-[2-(2,6-dichloro-4-fluorophenoxy)ethoxy]thiazol-5-yl}-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

HRID 1096869

반응식

HRID 1096869 반응식
[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:10]([CH2:11][C:12]([C:40]3[S:44][C:43]([O:45][CH2:46][CH2:47][OH:48])=[N:42][CH:41]=3)=[C:13]2[C:24](=[O:39])[N:25]([CH:36]2[CH2:38][CH2:37]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[C:28]=2[CH3:35])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:49][C:50]1[CH:55]=[C:54]([F:56])[CH:53]=[C:52]([Cl:57])[C:51]=1O>>[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])[CH:10]([CH2:11][C:12]([C:40]3[S:44][C:43]([O:45][CH2:46][CH2:47][O:48][C:51]4[C:50]([Cl:49])=[CH:55][C:54]([F:56])=[CH:53][C:52]=4[Cl:57])=[N:42][CH:41]=3)=[C:13]2[C:24](=[O:39])[N:25]([CH:36]2[CH2:37][CH2:38]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[C:28]=2[CH3:35])[CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

참가 물질

3

반응물 2

HCID 94950Phenol, 2,6-dichloro-4-fluoro-HCID 685707976-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-[2-(2-hydroxyethoxy)thiazol-5-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

생성물 1

HCID 690879976-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-{2-[2-(2,6-dichloro-4-fluorophenoxy)ethoxy]thiazol-5-yl}-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

실험 절차

This compound is prepared from compound E9 and 2,6-dichloro-4-fluorophenol, according to the above-described procedure A. LC-MS: tR=1.24 min, ES+: 847.35.

출처 및 근거

ORD 기록
ord-d2e17cc8e6644ca7aecbfb3e261f2f6e
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138340B2

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