Triethyl orthoacetate → Methyl 4-(2-methyl-1,3-oxazol-5-yl)-3,5-dimethoxybenzoate

HRID 1096989노트

반응식

HRID 1096989 반응식
Cl.[NH2:2][CH2:3][C:4]([C:6]1[C:15]([O:16][CH3:17])=[CH:14][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:8][C:7]=1[O:18][CH3:19])=[O:5].[C:20](OCC)(OCC)(OCC)[CH3:21]>>[CH3:20][C:21]1[O:5][C:4]([C:6]2[C:7]([O:18][CH3:19])=[CH:8][C:9]([C:10]([O:12][CH3:13])=[O:11])=[CH:14][C:15]=2[O:16][CH3:17])=[CH:3][N:2]=1

참가 물질

3

반응물 2

HCID 66221Triethyl orthoacetateHCID 66782707Methyl 4-(aminoacetyl)-3,5-dimethoxybenzoate hydrochloride

생성물 1

HCID 57930976Methyl 4-(2-methyl-1,3-oxazol-5-yl)-3,5-dimethoxybenzoate

반응 조건

온도
140 °C

실험 절차

Methyl 4-(aminoacetyl)-3,5-dimethoxybenzoate hydrochloride was dissolved in triethyl orthoacetate, paratoluenesulfonic acid monohydrate (10 mg) was added to it, and stirred at 140° C. for 6 hours. The reaction liquid was cooled to room temperature, then triethyl orthoacetate was evaporated away under reduced pressure, and the residue was purified through silica gel column chromatography (hexane/ethyl acetate=100/0 to 30/70) to obtain the title compound.

후처리

  1. customThe reaction liquid
  2. temperaturewas cooled to room temperature
  3. customtriethyl orthoacetate was evaporated away under reduced pressure
  4. customthe residue was purified through silica gel column chromatography (hexane/ethyl acetate=100/0 to 30/70)

출처 및 근거

ORD 기록
ord-01dc5985ce724fab93919cb95bc03515
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08138197B2

반응 노트

불러오는 중…