Dimethylformamide → HCID 86227722, 화합물

HRID 1097583노트

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HRID 1097583 반응식
C(N(CC)CC)C.[Cl:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17](Cl)[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1.CN(C=O)C.Cl.[F:29][C:30]([CH3:34])([CH3:33])[CH2:31][NH2:32]>O>[Cl:8][C:9]1[C:18]([N+:19]([O-:21])=[O:20])=[C:17]([NH:32][CH2:31][C:30]([F:29])([CH3:34])[CH3:33])[C:16]2[C:11](=[CH:12][CH:13]=[CH:14][CH:15]=2)[N:10]=1

참가 물질

6

반응물 4

HCID 6228DimethylformamideHCID 8471TriethylamineHCID 27851382,4-Dichloro-3-nitroquinolineHCID 552896302-Fluoro-2-methylpropan-1-amine hydrochloride

생성물 1

HCID 86227722HCID 86227722, 화합물

시약·촉매·용매 1

HCID 962Water용매

실험 절차

Triethylamine (2.76 g, 27.3 mmol) was added to a mixture of 2,4-dichloro-3-nitroquinoline (André et al, U.S. Pat. No. 4,988,815, Example 2, 4.44 g, 18.2 mmol) and DMF (50 mL), and then 2-fluoro-2-methylpropan-1-amine hydrochloride (2.5 g, 20 mmol) was added. The reaction was stirred at room temperature overnight and then poured into water (500 mL). The resulting mixture was stirred for 15 minutes. A solid was present and was isolated by filtration to provide 4.8 g of 2-chloro-N-(2-fluoro-2-methylpropyl)-3-nitroquinolin-4-amine as a yellow solid.

후처리

  1. stirringThe resulting mixture was stirred for 15 minutes
  2. customwas isolated by filtration

출처 및 근거

ORD 기록
ord-d57f10bd3edc4b13b5d8637086681b4d
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143270B2

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