N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide → 1-(3-Pentafluoroethyl-phenyl)-ethylamine

HRID 1098750

반응식

HRID 1098750 반응식
[F:1][C:2]([F:19])([C:7]1[CH:8]=[C:9]([C:13]([NH:15]C(=O)C)=[CH2:14])[CH:10]=[CH:11][CH:12]=1)[C:3]([F:6])([F:5])[F:4]>CO>[F:1][C:2]([F:19])([C:7]1[CH:8]=[C:9]([CH:13]([NH2:15])[CH3:14])[CH:10]=[CH:11][CH:12]=1)[C:3]([F:4])([F:6])[F:5]

참가 물질

3

반응물 1

HCID 59506293N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide

생성물 1

HCID 723100481-(3-Pentafluoroethyl-phenyl)-ethylamine

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

To a solution of N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide (110 mg, 0.39 mmol) in methanol (10 ml) was added (+)-1,2-bis((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium (I) trifluoromethanesulfonate (0.3 mg). The reaction mixture was hydrogenated with H2 at 5 bar and evaporated. The residue was dissolved in ethanol and hydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days. Purification by preparative HPLC and lyophilization of the relevant fractions gave the desired product.

후처리

  1. customevaporated
  2. dissolutionThe residue was dissolved in ethanol
  3. temperaturehydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days
  4. customPurification by preparative HPLC and lyophilization of the relevant fractions

출처 및 근거

ORD 기록
ord-68bd9dcb77a841f693a53736ac5ad86d
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143242B2

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