(1R,2S)-1-[(1-isopropyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine → (1R,2S)-1-[(1-cyclopentyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine

HRID 1098921노트

반응식

HRID 1098921 반응식
[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][C:11](I)=[CH:12][CH:13]=3)[CH:8]=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N1C2C(=CC([O:28][C@H:29]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[C@@H:30]([NH2:32])[CH3:31])=CC=2)C=N1)(C)C>>[CH:1]1([N:6]2[C:14]3[C:9](=[CH:10][C:11]([O:28][C@H:29]([C:33]4[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=4)[C@@H:30]([NH2:32])[CH3:31])=[CH:12][CH:13]=3)[CH:8]=[N:7]2)[CH2:5][CH2:4][CH2:3][CH2:2]1

참가 물질

3

반응물 2

HCID 59339639(1R,2S)-1-[(1-isopropyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amineHCID 593397901-cyclopentyl-5-iodo-1H-indazole

생성물 1

HCID 59339798(1R,2S)-1-[(1-cyclopentyl-1H-indazol-5-yl)oxy]-1-phenylpropan-2-amine

실험 절차

Prepared from 1-cyclopentyl-5-iodo-1H-indazole (130c, 158 mg, 500 μmol) as described for 129b. Yield 34 mg (20%).

출처 및 근거

ORD 기록
ord-1e3f939edfee46dd8cf96ae7972b4678
출처 데이터셋
uspto-grants-2012_03
특허 번호
US08143290B2

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